Human epidermal stem cells in the progress of Burns and Plastic Surgery.docVIP

 PAGE \* MERGEFORMAT 17 Human epidermal stem cells in the progress of Burns and Plastic Surgery [Keywords:] Burns and Plastic Surgery, human epidermal stem cells The skin is the largest organs of the body, covering the appearance of the body is burned on the main contents of plastic surgery. In Burns, the epidermal stem cells (Epidermal stem cel1, ESC) has unquestioned potential, it is the skin tissue-specific stem cells in maintaining self-renewal of the epidermis, the skin to maintain skin structure and function of the normal play an important role. Currently tissue reconstruction using stem cells and transgenic studies to become an important direction in the biomedical field, this article on the epidermal stem cell research are reviewed. 1 ESC definition and positioning Stem cells that originated cells, is not yet mature cells, with multiple differentiation potential and self-renewal and self-replication capabilities, under certain conditions can differentiate into different tissues and organs, in gene regulation may be in accordance with the development of ways to split the divisive cells, it can be said of the differentiated cells, stem cells act as a “reserve.” Maintain life-long proliferation of ESC, is a variety of epidermal cell proliferation and differentiation of stem cells. On the epidermal cell culture studies have found, according to its growth potential can be divided into three categories: (1) complete clone (holoclone) cells, which stem cells (stem cel1), or tag retention cells (1abel retaining cell, LRC), has strong potential for growth and proliferation, (2) between the ecological clone (paraclone), the temporary expansion of cells (transit ampli-fying cell, basal layer ), (3) terminally differentiated cells - squamous cells. epidermal basal cells, only 1% -10% for the ESC, and increased with age, ESC reduced the number of subsequent [1,2] . ESC a stem cell common features: (1 slow cyclical: the performance of somatic c