HPV16 E6-E7 protein and Rb protein in human laryngeal squamous cell carcinoma and correlation of.docVIP

 PAGE \* MERGEFORMAT 10 HPV16 E6/E7 protein and Rb protein in human laryngeal squamous cell carcinoma and correlation of Of: Ye, Bi Jie, Zhang Ting, Chen Jue, Miao-Xin Qiu [Abstract] Objective To observe the expression of HPV16 E6/E7 early genes in the protein and Rb protein in laryngeal carcinoma correlation of etiology of laryngeal cancer provide the basis for exploration. Methods detected by immunohistochemistry in 82 cases of laryngeal squamous cell carcinoma, 39 cases non-cancerous tissue samples, and HPV16 E6/E7 expression of Rb protein. Results (1) HPV16 E6/E7 and the positive rate of Rb protein in non-cancer and laryngeal carcinoma statistically significant difference (P lt;0.01), HPV16 E6/E7 and the positive rate of Rb protein in non-cancer tissues showed significantly negative correlation (P lt;0.01); (2) laryngeal carcinoma, Rb protein in HPV16 E7-positive and-negative groups, the positive rate was significantly different ( P lt;0.01), while HPV16 E6 and no such phenomenon in non-cancerous tissues (Pgt; 0.05). conclusions of laryngeal carcinoma is the high expression of HPV16 E7 protein functional inactivation of Rb result in the main. [Keywords:] Laryngeal neoplasms; carcinoma, squamous cell; HPV16 E6 protein; HPV16 E7 protein; Rb protein [Abstract] Objective Observing the correlation of expression of HPV16 E6/E7 and Rb proteins in human laryngeal squamous cell carcinoma to give gists for the etiology search of laryngeal carcinoma.Methods The expression of HPV16 E6/E7 and Rb proteins were detected by the immunohistochemical method in 82 specimens with laryngeal squamous cell carcinoma and 39 specimens with non-carcinoma.Results (1) Between non-carcinoma and laryngeal squamous cell carcinoma tissues, there were different positive rates for the HPV16 E6/E7 and Rb proteins (P lt;0.01 ). Between the positive rates of the expression of HPV16 E6/E7 and Rb proteins, there were negative correlation significantly in non-carcinoma tissues (P lt;0.