HPV and cervical cancer and p16INK4A Progress.docVIP

 PAGE \* MERGEFORMAT 18 HPV and cervical cancer and p16INK4A Progress [Abstract] p16INK4A gene determines the normal operation of the cell cycle and cell proliferation, differentiation and apoptosis, and human development on a variety of tumors. P16INK4A in the absence of most primary tumors, but in cervical cancer and precancerous lesions expression than others. high risk human papilloma virus (high risk human papilkmavirus, HR HPV in cervical cancer play an important role in the development process. In this paper, p16, HPV in cervical cancer research reviewed in this paper. [Keywords:] p16INK4A human papillomavirus cervical CIN A variety of malignant cervical cancer in women after breast cancer incidence rate in the second highest, while the rise in recent years. Cervical cancer is a multi-factor, multi-step long-term process, involving multiple genes induced changes in cell proliferation control. a large number of studies confirm the etiology of cervical cancer and high-risk human papillomavirus infection. HR HPV infection in cervical cancer and precancerous lesions appear abnormal expression of p16INK4A, p16INK4A and HPV infection in the relationship between cervical cancer, has become a research hotspot in recent years. 1 HPV of the structure, function and the mechanism of carcinogenesis of cervical tumors HPV is a double-stranded closed circular DNA virus of small molecules, molecular weight 5000KD, a diameter of 55 nm, shell particles by 72 to 20 constitute the clothing side of the shell, no capsule, and its gene in the total length of about 8kb, except for some regulatory sequences (Long control region, LCR, the other composed of eight genes, including six early genes (E6, E7, E1, E2, E4, E5, and two late genes (L2, L1.L1 genes conserved DNA sequences has been used for identification and typing of HPV basis. It has been nearly a hundred HPV types are separated to determine. according to their oncogenic properties of the genital tract of t