Hydrochloride nolatrexed tumor inhibition in mice transplanted experimental study.docVIP

 PAGE \* MERGEFORMAT 11 Hydrochloride nolatrexed tumor inhibition in mice transplanted experimental study Authors: fang, Duwei Xia, Fu Ying-hua, ZHOU Xiang-yan, DONG Jin-chan [Abstract] Objective To observe the hydrochloride nolatrexed (THY-110) in mice transplanted liver (H-22), Ehrlich ascites carcinoma (EAC) and sarcoma (S-180) in vivo. Methods The experiment used Kunming mice, weighing 18 ~ 22g, evenly divided male and female. Set up 80,120, and 180mg/kg body weight three dosage groups, a positive control group and a solvent control group. Mice were inoculated through the left forelimb armpit 0.2ml (1 * 107/ml) suspension of tumor cells after inoculation by intraperitoneal injection of administration for 10 days. After stopping the tumor and said stripping tumor weight to calculate tumor inhibition rate, experiments were repeated 3 times. Results hydrochloride nolatrexed right liver, Ehrlich ascites cancer and sarcoma, the inhibitory rate of high, medium and low-dose group were: (70.23 ± 3.1)%, (66.3 ± 6.2)%, (46.8 ± 3.7)% ; (69.1 ± 1.4)%, (59.7 ± 6.6)%, (43.8 ± 5.9)%; (73.8 ± 1.7)%, (64.1 ± 4.2)%, (42.2 ± 4.7)%. Conclusion hydrochloride nolatrexed significant inhibition of tumors. [Keywords:] hydrochloride nolatrexed (THY-110); transplantation; tumor inhibition rate Study on effect of tumor control by abdominal cavity injection of THY-110 for mice LU Hui-min, DU Wei-xia, FU Ying-hua, et al. Institute of Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China [Abstract] Objective To investigate the treatment effect of liver cancer H-22, EAC cancer and S-180 by abdominal injection of THY-110 in mice.Methods Mice were divided to five groups including THY-110 doses groups of 80, 120 and 180mg/kg body weight; solvent group and positive control group. 0.2ml (1 * 107/ml) tumor cell solution were inoculated to mice at fore limb subaxilla. After inoculation, mice were continuously injected of THY-110 for 10 days, tumor ti