Hydroxy piperaquine phosphate on the blood system radiation injury in rats.docVIP

 PAGE \* MERGEFORMAT 12 Hydroxy piperaquine phosphate on the blood system radiation injury in rats [Abstract] Objective To study the phosphorylation of hydroxy-piperaquine the blood system of irradiated mice the protective effect. Methods 40 mice were randomly divided into 5 groups (HPQP low, medium and high dose group and blank control group and normal group), In addition to the normal group, the rest of the group were given 4.5 Gy60Co- irradiation, the WBC and platelet counts in mice after radiation observed changes in the blood system, we observe the impact of drugs on the blood system and to select the appropriate dose of drug ; In another 24 mice were randomly divided into 3 groups (treatment group and the control group, normal group) to determine the phosphorylation of hydroxyl groups after the optimal dose of piperaquine oral administration before irradiation, to 9.0 Gy 60Co- ray total body irradiation, 9 days after irradiation, mice were killed, spleen nodules method, bone marrow nucleated cell counts, bone marrow pathological observation of drug effects on hematopoietic function in mice. Results hydroxy piperaquine phosphate can promote the recovery WBC after radiation (P lt;0.01), lower mortality (P lt;0.01), the splenic nodules (CFU-S) the number of bone marrow cells was significantly increased (P lt;0.01). Conclusion hydroxy piperaquine phosphate on the blood of irradiated mice system protection. [Keywords:] hydroxy piperaquine phosphate; radiation damage; blood system; bone marrow; mice Abstrsct: Objective To investigate the protection effect of hydroxypiperquin phosphate (HPQP) on hematological system injury induced by radiation damage in mice. Methods 40 male Kunming mice were randomly divided into five groups (low / middle / high dose groups, blank control group and normal group). All except the normal group underwent whole-body -ray irradiation at 4.5 Gy. The peripheral leukocyte and platelet counts were determined for the primary effe