Human immunodeficiency virus-associated nephropathy.docVIP

 PAGE \* MERGEFORMAT 17 Human immunodeficiency virus-associated nephropathy In recent years, awareness of human immunodeficiency virus-associated nephropathy (human immunodeficiency virus-associated nephropathy, HIVAN) of treatment made some useful attempts. In these early studies, routine immunization is equally effective inhibitors of the HIVAN? Can promote the occurrence of HIV infection in the development? HIVAN whether to increase the risk of opportunistic infections in patients with combined? HIV infection in end-stage renal disease (ESRD) in patients with hemodialysis (HD ) in the treatment will result in HIV cross-infection between patients in hemodialysis? If cross-infection What are the possible ways? HIV can spread in renal transplant patients, anti-retroviral therapy in renal transplant patients is safe and a series of problems researchers and patient focus. This paper will present the following two aspects of the progress made in the treatment of HIVAN to do an overview of: ① in the early kidney disease to prevent progression to ESRD treatment carried out; ② against HIV infection in the treatment of patients with ESRD. 1 ESRD pre-treatment 1.1 Glucocorticoid preliminary clinical studies have shown that corticosteroids can improve renal function in adult patients with HIVAN, reduce urinary protein [1 ~ 4], reducing renal vascular disease and mitigate the tubulointerstitial inflammation [2], but the reduction of serum creatinine (SCr) concentration increased again [2] and for some children with HIVAN is invalid. Affect the efficacy of glucocorticoid main factors of HIV infection in synergy factor, infection stage and age of the patient. Glucocorticoid mechanism of action is not yet precise, and is now a clear and impact of interstitial immune cells in the [2], while glucocorticoids may also directly affect the glomerular filtration rate (GFR) and glomerular basement membrane permeability . Glucocorticoid treatment HIVAN major complications of o