HSH injection infusion on acute intracranial hypertension associated with hemorrhagic shock in dogs brain tissue pathology and the impact of oxygen free radicals.docVIP

 PAGE \* MERGEFORMAT 8 HSH injection infusion on acute intracranial hypertension associated with hemorrhagic shock in dogs brain tissue pathology and the impact of oxygen free radicals [Abstract] Objective To observe the hypertonic saline hydroxyethyl starch 40 injection (HSH) in dogs with acute intracranial hypertension associated with hemorrhagic shock model in the recovery cycle of blood volume, reduced brain edema and reduce the brain tissue content of oxygen free radicals effect. Methods 20 healthy dogs, using epidural balloon method of water injection and arterial bleeding associated with the acute intracranial hypertension model of hemorrhagic shock. Animals were randomly divided into group of hydroxyethyl starch solution (HES group), lactate Ringer’s solution group (RL group), 7.5% sodium chloride solution group (HS group) and hypertonic saline hydroxyethyl starch 40 injection group (HSH group), respectively, in the shock 1h Enter the appropriate liquid. Monitoring of mean arterial pressure (MAP), central venous pressure (CVP), heart rate (HR), intracranial pressure (ICP), detection of brain tissue malondialdehyde (MDA) content, superoxide dismutase (SOD) activity, brain tissue for histopathologic examination. Results 4 groups after resuscitation fluid can effectively increased MAP (P lt;0.05), but the HES group and RL group, ICP increased significantly (P lt;0.05), recovery after 2h, HS group, MAP started to decline (P lt;0.05). To recover after 4h, only to maintain a favorable HSH group MAP and lower ICP, HSH group of brain tissue content of oxygen free radicals compared with other groups decreased (P lt;0.05). Pathological examination showed that the recovery after 4h, HSH group of brain tissue damage compared with other groups of light. Conclusion hypertonic saline hydroxyethyl starch 40 injection can effectively recover hemorrhagic shock, reduced ICP and oxygen free radical generation, reducing cerebral ischemia-reperfusion injury. [Keywords:] Hy