Hydrophilic drugs liposomes Discussion.docVIP

 PAGE \* MERGEFORMAT 18 Hydrophilic drugs liposomes Discussion Keywords: Preparation of hydrophilic drug-liposome I. Introduction Liposomes as a novel drug carrier system, this year is widely used and research. Evaluation of the quality indicators liposomes appearance, size distribution and encapsulation rate. Encapsulation efficiency of which is a measure of lipids in vivo is an important indicator of quality. For lipophilic drugs, because of its affinity to the lipid membrane can be obtained in the course in the preparation of a high encapsulation efficiency, and difficult to leakage. The hydrophilic drugs in the preparation of time must be encapsulated in the lipid vesicle liposomes internal or multi-layers of water-based medium, in addition to some special drug outsourcing closure rates are generally not high, and easy to leak. Preparation in order to get a greater encapsulation efficiency had increased capsule volume, which in and control the size of liposomes within the framework of effective and mutually contradictory. The following will introduce a number of drugs used to enhance the hydrophilicity of the liposome entrapment efficiency of the method. 2, preparation method 1, conventional methods For some hydrophilic drugs, using conventional preparation methods can also receive a satisfactory entrapment efficiency. Hu Jing, etc. (1) with a simple thin-film hydration - mechanical dispersion was studied by azathioprine (Aza) liposome encapsulation efficiency of the influencing factors. These factors include lecithin and bile alcohol molar ratio, the buffer solution (PBS) pH value of aqueous drug dosage and lipid weight ratio. Get the best prescription by orthogonal design obtained by the three groups azathioprine liposomes form a whole circle, size uniformity, particle size range of 0.01 ~ 0.42μ m, each contributed more than 30% encapsulation efficiency. But the drugs were found in experimental lipid weight ratio increased, the encapsulation effic