I anti-fibrosis compound on alcoholic liver disease liver sinusoidal endothelial cells.docVIP

 PAGE \* MERGEFORMAT 8 I anti-fibrosis compound on alcoholic liver disease liver sinusoidal endothelial cells [Abstract] Objective To investigate the anti-fibrosis compound I, in alcoholic liver sinusoidal endothelial cells (liver sinusoidal endothelial cell, LSEC. Methods 63 rats were randomly divided into normal group, alcohol group and TCM group, according to the chamber method with ethanol and anti-fibrosis Compound I, (Kang Xian Fu Fang I, KXI) direct gavage, at 4 weeks, 8 weeks, rats were sacrificed 12 weeks, HE staining to observe the pathological changes, transmission electron microscopy sinusoidal capillarization. Results With the development of alcoholic liver disease, pathological changes in the Medicines and formation of sinusoidal capillarization was significantly reduced compared with the alcohol. Conclusion I, anti-fibrosis compound can prevent alcoholic liver sinusoidal capillarization formation. [Keywords:] alcoholic liver sinusoidal endothelial cells in anti-fibrosis compound I, In the process of liver fibrosis, LSEC of fenestrae decreased or disappeared, the formation of subendothelial basement membrane, the shape of continuous capillaries, a process known as sinusoidal capillarization. It is the most basic features of hepatic fibrosis. Recently The results show that sinusoidal capillarization in the non-alcoholic liver disease plays an important role in the pathogenesis [1], but it is in alcoholic liver disease know very little about the role of the process. We observed by ethanol gavage pathological liver changes, and changes in the dynamic observation of LSEC morphology and anti-fibrosis compound I, of. 1 Materials and methods 1.1 Materials 8 weeks old Wistar male rats 63, body weight (170 grams + -20 grams, by the experimental animal department of China Medical University. Randomized control group, alcohol group and TCM group (KXI group, 21 rats in each group. By day and night schedule, and stable at room temperat