IgA nephropathy in children with primary diagnosis and treatment of 14 cases.docVIP

 PAGE \* MERGEFORMAT 12 IgA nephropathy in children with primary diagnosis and treatment of 14 cases Keywords: kidney disease Shi Yajuan, Shenyang City, Children’s Hospital within the 2 Branch (110032), First Affiliated Hospital of China Medical University, Department of Pediatrics at the time Master IgA nephropathy (IgAN) is a common primary glomerular disease of children, one of the early days that the good prognosis of this disease, but recent research found that in 10 years after diagnosis is about 15% ~ 25% of the children progressed irreversibly end-stage renal disease. Now 14 cases of children admitted to the diagnosis and treatment of IgAN reported as follows. A clinical data 1.1 General Information 2001  10 ~ 2006  07 at the First Affiliated Hospital of China Medical University Pediatric renal biopsy by pathological diagnosis for children with primary IgAN in hospitalized children in 14 cases, including 9 males and 5 females, male to female ratio 1.8: 1. Age 5 ~ 14 (8.9 ± 2.6) years of age. To exclude allergic purpura, systemic lupus erythematosus, chronic liver disease such as caused by secondary IgAN diagnosed after the disease. This group of children IgAN accounted for 17.9% of renal biopsy in the same period. 1.2 Clinical classification According to 2001 Branch of the Chinese Medical Association Pediatric Nephrology Group to develop standards for classification of the Zhuhai meeting [1]. 1.3 Laboratory tests 14 cases were detected urine routine, serum albumin, 24 h urine protein, 24 h creatinine clearance rate and serum creatinine, uric acid, blood lipids, IgA, autoantibodies ANA (antinuclear antibody), ds  DNA (double-stranded DNA), and hepatitis B virus marker. 1.4 Pathological examination Renal biopsy specimens were done by light microscopy, immunofluorescence. Diagnosis based on biopsy immunofluorescence in the mesangial area and (or) capillary loop has to