IL-11 Clinical Research.docVIP

 PAGE \* MERGEFORMAT 17 IL-11 Clinical Research Keywords:: Interleukin -11; of hematopoietic system; bone marrow; non-hematopoietic effects of Abstract Interleukin -11 (IL-11) alone or in combination with other cytokines, can stimulate the expansion of primitive stem cells and to the committed stem cell differentiation, the promotion of bone marrow erythroid, granulocyte, lymphatic system, the generation of megakaryocyte cell line. IL-11 can inhibit the growth of gastrointestinal epithelial cells, promoting the role of broken bones, inhibit the formation of bone nodules, and is an important sensory and motor nerve growth factor. This article also describes the IL-11 in hematopoietic and non-hematopoietic system, pre-clinical and clinical research in period. Keywords: Interleukin -11; of hematopoietic system; bone marrow; non-hematopoietic effects of 1 IL-11 to promote the role of hematopoietic 1.1 The progenitor cell growth and differentiation [4] IL-11 and other roles in the early or late hematopoietic growth factor synergy to stimulate hematopoietic cell growth and differentiation. IL-11 and IL-3, IL-4, IL-7, stem cell factor (Stem cell factor, SCF), flt3-L, GM-CSF synergy to stimulate from the umbilical cord blood, bone marrow (BM), peripheral blood different culture systems, different sources of primitive stem cells, multipotent stem cells and committed stem cell proliferation. This amplification effect may be due to IL-11 promotes cell from the G0 phase to enter the cell cycle. In some cells, IL-11 still capable of reducing cell cycle time. And the hematopoietic microenvironment of the other cytokines in combination, IL-11 can increase the original ancestor of pluripotent stem cells, cell differentiation, and stimulate the directional amplification and differentiation of stem cells. With the IL-11 and SCF in vitro expansion of BM cells, can enhance the short-term migration potential, this expansion of cells in lethally irradiated mice caused by se