Imidapril and fosinopril on myocardial ultrastructure in diabetic rats.docVIP

 PAGE \* MERGEFORMAT 11 Imidapril and fosinopril on myocardial ultrastructure in diabetic rats Analysis: Min Liao Meimei Xinwen Yang Handong Xiongshi Xi Xiao Ran [ABSTRACT] Objective imidapril (up to cool and fosinopril (Monnow two kinds of angiotensin converting enzyme inhibitors (ACEI in experimental diabetic rats, early intervention, the two drugs observed in the diabetic rat heart The role of ultrastructure. Methods Streptozotocin on the 30 SD rats were injected intraperitoneally to establish experimental diabetic rat model. the successful modeling of diabetic animals were divided into groups (nine, Amy Dapp Lee intervention group (9, fosinopril group (10 rats take another 10 SD rats were used as normal control group .10 w, observe myocardial ultrastructure of rats. Results In diabetic rats Traveling cardiac myofibrils disorders, muscle damage section fracture, different lengths, focal myofilament dissolution, disappears, the intercalated disk array with breaking phenomenon, mitochondrial swelling deformation and ridge sparse, disordered structure is unclear. myocardial microvascular basement membrane thickened interstitial collagen fibrosis. fosinopril imidapril treatment group and myocardial ultrastructure in both treatment groups improved, fosinopril better. Conclusions and fosinopril can Imidapril delayed myocardial ultrastructure in rats with experimental diabetic pathological changes in the latter than the former. [Keywords:] ultrastructure, imidapril, fosinopril, diabetes [Abstract] Objective To investigate the effect of imidapril and fosinopril on myocardial morphological changes of diabetic mellitus (DM) rats.Methods 40 male SD rats were randomly divided into two groups, 10 as normal control group and the others as DM models induced by streptozotocin (STZ) .28 rats were successfully induced into DM.Then they were divided into DM, imidapril treated and fosinopril treated groups.Myocardial morphology was observed. Results After the trea