Insulin resistance in the pathogenesis of essential hypertension in the role of.docVIP

 PAGE \* MERGEFORMAT 11 Insulin resistance in the pathogenesis of essential hypertension in the role of [Key Words] essential hypertension; insulin resistance (IR); hyperinsulinemia Hypertension is high blood pressure as the main clinical manifestations with or without the syndrome, multiple cardiovascular risk factors, referred to as hypertension. Hypertension is a variety of important cardiovascular disease etiology and risk factors The etiology is complex, and that the main factors of genetic predisposition and environmental interaction. pathogenesis of hypertension has yet to complete and unified understanding, mainly on the following link [1]: (1) sympathetic nervous system activity hyperthyroidism; (2) renal Shuinazhuliu; (3) renin-angiotensin-aldosterone system (RAAS) activation; (4) abnormal cell membrane ion transport; (5) other factors such as insulin resistance. This review focuses on insulin resistance in the primary the pathogenesis of hypertension Overview of the role. Reaven first proposed in 1988, insulin resistance syndrome or metabolic syndrome, since many studies show that the IR and hypertension is closely related to the severity of blood pressure and the degree of IR was positively correlated [2]. Research has shown that high primary blood pressure, plasma insulin levels were significantly higher in patients with secondary hypertension without IR phenomenon, suggesting that IR may be reasons for the incidence of hypertension [3]. many of the biological effects of insulin, now referred to as insulin in promoting glucose IR impaired uptake and utilization of blood circulating insulin biological effects below the expected normal level, this time as much as possible to the body to maintain normal glucose levels and compensatory secretion of too much insulin, leading to hyperinsulinemia, resulting in elevated blood pressure [4]. but the blood levels of insulin on target tissues depends not only on glucose metabolism, but also by the amo