Insulin-like growth factor-I and diabetic cognitive dysfunction.docVIP

 PAGE \* MERGEFORMAT 17 Insulin-like growth factor-I and diabetic cognitive dysfunction [Keywords:] insulin-like growth factor-I dysfunction in diabetes knowledge Cognitive dysfunction with diabetes a chronic complications of Diabetes, mainly the decline in learning ability and memory function damage Type 1 diabetes leads to cognitive dysfunction was mainly due to repeated episodes of low blood sugar caused by, and with diabetes age, duration, number of episodes of low blood sugar, metabolic control of the situation and other factors [1,2], and type 2 diabetes lead to cognitive dysfunction is a multi-factor, the pathogenesis of multi-link with brain aging and Al Zihai silent disease (Alzheimer disease, AD) are closely related [3]. Insulin-like growth factor-I (IGF-I) as a homology with the insulin peptide neurotrophic factors, both have a certain kind of metabolism of insulin, but also has some kind of nerve growth factor neurotrophic effects. Physiological state of the central nervous system has a broad expression of IGF- [4]. Studies have shown diabetes brain IGF-I levels to change. SHENG tree force [5] found that diabetic mice brain insulin-like growth factor-I receptor (IGF-IR distribution of the location and content increased. Therefore, some scholars have recognized that IGF-I and diabetes, cognitive function must necessarily exist between the relationship and did some research, the current results in the following areas: 1 insulin-like growth factor-I, neurotrophic effects Ultrastructure of the cortex of diabetic hamsters showed cerebrovascular damage, abnormal axonal mitochondria, axonal degeneration and neuronal loss, seen under an electron microscope and degeneration of neurons astrocytes degeneration. Also in diabetic patients found in the neural pathology, there is meningeal fibrosis, cerebrovascular disease, pseudo-calcinosis and severe diffuse white matter and gray matter degeneration. IGF-1 as a neurotrophic factor, not only the oc