Interferon induced depression in elderly patients with hepatitis C and the relationship between low thyroid function.docVIP

 PAGE \* MERGEFORMAT 8 Interferon induced depression in elderly patients with hepatitis C and the relationship between low thyroid function OF: SOCIETY OF Fangshu Qin Zhang Wenbin Wang Xinyi Liu Jinxia [Abstract] Objective To investigate the interferon induced depression in elderly patients with hepatitis C and thyroid hormone levels. Methods detected by chemiluminescence sex and age in patients with chronic hepatitis C during interferon treatment of 12 w changes in thyroid hormone levels, the use of Zung self depression scale (ZDS) for psychological evaluation. Results of interferon treatment of hepatitis C in elderly female patients with thyroid hormone compared with the control group, TSH increased, FT3, FT4 was significantly lower, and lower than the level before treatment (P lt;0.05, integral value of older women significantly increased in patients with depression, and older males, young group there was significant difference (P lt;0.001, negative correlation between (P lt;0.05. Conclusion interferon therapy process, older women were more prone to hypothyroidism and depression symptoms in patients with thyroid dysfunction may be one of the reasons depression in the course of antiviral therapy, it is necessary to add thyroid hormone to reduce depression in patients with clinical symptoms and performance. [Keywords:] pegylated interferon, thyroid hormones, age, sex, chronic hepatitis C Pegylated interferon (PEG IFN @ 2a treatment of chronic viral hepatitis (chronic hepatitis C) has made a good long-term effect, or even be cured. However, its often serious adverse effects and patient compliance treatment, especially in older women with hypothyroidism were significantly higher than male and young patients (1), or even old age depression. The process by detecting interferon in patients with thyroid hormone levels of depressive symptoms and occurrence of thyroid the relationship between hormone levels to find the cause of depressive symptoms and trea