Intrathecal injection of rat diazepam rectal visceral pain induced by injection of formaldehyde.docVIP

 PAGE \* MERGEFORMAT 7 Intrathecal injection of rat diazepam rectal visceral pain induced by injection of formaldehyde Author: Mr Peter Wong;, Deng Jiao, Liu Bing, Yu-jun, FU Wen-ying [Keywords:] visceral pain Suppressive effect of intrathecal administration of diazepam on visceral pain induced by rectal instillation of formalin in rats [Abstract] AIM: To explore whether diazepam has a suppressive effect on visceral pain at the spinal level. METHODS: By intrathecal drug administration, the effect of diazepam on persistent visceral pain induced by rectal instillation of formalin was studied. RESULTS: Rectal instillation of formalin induced obvious visceral pain responses, which occurred mainly within 0 ~ 75 min after the rectal administration of formalin. Intrathecal pretreatment with three doses of diazepam suppressed the visceral pain responses induced by formalin and the analgesic action of diazepam was mainly within 0 ~ 60 min after the rectal administration of formalin. CONCLUSION: Intrathecal pretreatment with diazepam suppresses the visceral pain induced by rectal instillation of formalin, which suggests that diazepam exerts some suppressive effect on visceral pain at the spinal level. [Keywords] diazepam; visceral pain; formaldehyde; latency [Abstract] Objective: To study the level of diazepam in the spinal cord whether the inhibitory effect on visceral pain. Methods: The Methods of intrathecal administration of diazepam rectal injection of formaldehyde in rats induced by inhibition of persistent visceral pain. Results: ① rectal injection of formaldehyde can cause severe visceral pain response in rats, pain, mainly in response to noxious stimulation in rats within 75 min after the rectum. ② prior intrathecal injection of three doses of diazepam can inhibit noxious stimulation in rats rectum induced visceral pain and analgesic effect mainly in the rectum after noxious stimulation 0 ~ 60 min. Conclusions: Intrathecal injection of diazepam into the