Intravenous infusion of irinotecan hydrochloride in patients with elevated blood pressure induced by 1 case.docVIP

 PAGE \* MERGEFORMAT 6 Intravenous infusion of irinotecan hydrochloride in patients with elevated blood pressure induced by 1 case [Keywords:] intravenous infusion of irinotecan hydrochloride blood pressure Irinotecan hydrochloride injection is inhibited by the antitumor DNA topoisomerase , mainly for patients with advanced colorectal cancer chemotherapy, late-onset major adverse reactions were diarrhea and acute cholinergic syndrome, rarely have caused blood pressure rise high coverage. 1 patient in our hospital after the application of the drug 3 times higher in blood pressure, consider drug related, are reported below. 1 Clinical data Patients, female, aged 67, for “blood in the stool six months” period in 2005, 11 colonoscopy and pathological diagnosis of cancer, history of physical health, denied hypertension, diabetes mellitus December .2005 radical rectal cancer surgery, pathology showed moderately differentiated adenocarcinoma, postoperative stage T2N1M0, 6 cycles of postoperative chemotherapy after the termination of FOLFOX therapy, periodic review. in the November 2007 review found that lung metastasis, liver metastasis, bone metastasis, then switch to FOLFIRI chemotherapy, the first course of treatment in the application of a hospital in Beijing, irinotecan (CPT infusion time, patients with dizziness, blood pressure 170/95 mmHg, for 10 mg sublingual nifedipine blood pressure gradually returned to normal, Monitoring blood pressure is normal after the second course of chemotherapy in our hospital back in the application of irinotecan (Alex infusion was again dizziness, increased blood pressure of 150/100 mmHg, symptomatic treatment for the symptoms improved, but still monitoring the blood pressure fluctuations at 150 ~ 170/85 ~ 100 mmHg, sustained 2 ~ 3 d, the third course of chemotherapy in the application of irinotecan infusion was again dizziness, increased blood pressure of 150 ~ 160/90 ~ 100 mmHg, monitored after chemotherapy blood pre