Ketamine anesthesia on canine brain function in fMRI imaging study of.docVIP

 PAGE \* MERGEFORMAT 6 Ketamine anesthesia on canine brain function in fMRI imaging study of [Keywords:] Ketamine; magnetic resonance imaging; anesthesia; brain fMRI study on effect of ketamine on cerebral function in dogs [Abstract] AIM: To study the changes of NMR signal intensity in dogs cerebral regions after ketamine application, and to investigate specific brain regions that are sensitive to the anesthetic. METHODS: Stimulation procedure was performed from consciousness, to sedation, to unconsciousness, and finally to analepsia. Scan lasted 60 Dy. Ketamine was injected at a dose of 2 mg / kg with a constant speed infusion pump. Functional magnetic resonance imaging (fMRI) was applied during the entire experiment. A dynamic singleshot EPI sequence was used to perform BOLD functional MR imaging on a 1.5T Philips Gyroscan MR system and the Functool software was also used to analyze these images. RESULTS: For the ketamine anesthesia groups, the decreased signal intensity was observed at sensory cortex (r = 0.79, 19.5%), at motor cortex (r = 0.81, 16.6%), at thalamus (r = 0.66, 4.5%), and at callosal gyrus (r = 0.68, 4.7%). The changes of signal intensity were synchonous. However, there was no significant change in other subcortex regions. CONCLUSION: Ketamine anesthesia suppressed such regions as sensory cortex, motor cortex, thalamus and callosal gyrus, which might be the key targets for ketamine action. [Keywords] ketamine; magnetic resonance imaging; Anesthesia; Brain [Abstract] Objective: To use magnetic resonance imaging to study the anesthetics ketamine on canine cerebral magnetic resonance signal intensity change, to explore the possible role of anesthetics in the brain parts. Approach: to stimulate use of conscious sedation procedures for the dynamic process of waking unconsciousness scanning for 60 dynamic. ketamine anesthesia by 2 mg / kg intravenous injection through the use of constant speed pumps, medication way for infusion. using 1.5T Ph