Leflunomide and clopidogrel in the treatment of refractory nephrotic syndrome in 47 cases.docVIP

 PAGE \* MERGEFORMAT 6 Leflunomide and clopidogrel in the treatment of refractory nephrotic syndrome in 47 cases [Keywords:] Leflunomide Refractory primary nephrotic syndrome, nephrotic syndrome is a frequent seizures in cases of steroid-dependent or resistant general. Adrenal cortical hormone for the treatment of nephrotic syndrome usually first-line drugs, however, some hormones and other immunosuppressive agents are not sensitive to the clinical treatment of patients is quite difficult; the continued use of hormones and immunosuppressive agents, not only can not be effective; the contrary, a result of a serious life-threatening complications, drawing on leflunomide treatment of lupus nephritis significant side effects reported [1]. Since 2003 we have applied leflunomide, fluorine imidacloprid Gray, medium-dose prednisone treatment of refractory nephrotic syndrome achieved good efficacy, these are as follows. 1 Data and methods 1.1 General Information 47 cases were observed, both our hospital out-patient cases, 20 males and 27 females, aged 19 to 58 years, with an average 35.5 years old, were treated for 4 to 9 months, were characterized by conventional-dose and cycles of strong pine treatment ineffective. In line with refractory nephrotic syndrome diagnostic criteria, biopsy showed two cases of membranous nephropathy, mesangial proliferative glomerulonephritis in 2 cases, moderate mesangial proliferative glomerulonephritis 30 cases of minimal change renal ball nephritis in 10 cases, focal segmental glomerulosclerosis in 3 cases. Were randomly divided into two groups, treatment group, 25 cases in the control group 22 cases, the two groups in gender, age, condition and other aspects of clinical difference was not significant. 1.2 treatment group was treated with a gradual reduction of prednisone, plus with leflunomide 50 mg / d * 3 days later, changed to 20 mg / d maintenance therapy, clopidogrel 25 mg, 2 times / d, strong Song reduced to 30 mg / d after