丙戊酸钠静脉滴注治疗偏头痛持续状态.pdfVIP

250 丙戊酸纳静脉滴注治疗偏头痛持续状态 顾萍储旭华丁新生 摘 要 目的:评估闵戊酸纳治疗偏头痛捋续状态的有效性和安全傲。方法:我们前瞻性地用静脉满注丙戊酸销来 治疗偏头痛持续状盔，然后比较患者治疗前与出院时视觉模拟评分 (VAS) 。并比较各种因素(一般情况，祟计的两戊酸 纳剂量，合并用药)与治州立间的关系。结果:首次治疗中， 26 次 (74.3%) 治疗时患者 VAS 评分较治疗前减少 50% 或 50% 以上。所有治疗中， 37 次 (82.2%) 治疗使患者 VAS 评分较治疗前减少 50% 或 50% 以上。患者的性别与治疗反应 元关。所有治疗中，合并用药(强痛寇，索密通，散粒痛和达宁〉和治疗时间与治疗反应最负相关。仅 3 例 (8.6%) 出现短 暂性眩缘。结论:丙戊酸纳静滴是快速，有效和安全的止痛治疗。它对偏头痛持续状态有效。 关键词 丙戊酸纳静滴偏头痛持续状态视觉模拟评分 中团分类号: R747 ? 2 文献标识码 :A 文巅编号: 1006 一 351X(2006)04 一 0250 … 03 Abstract Objective: 丁o evaluate the effectiveness of intravenous valproate in status migraine. Methods: We prospec? tively treated , in a nonrandomized and open-label study, every patient with status migraine who wanted treatment with in喃 travenous valproate. Using a verbal visual analog scale for pain , we measured head pain before treatment and at time of discharge. Information was co l1ected regarding patient demographics. observation time in the treatment suite. cumulative dose of valproate , and use of concurrent medications. Results: For first treatments only , 26 patients (74. 3 %) responded to treatment. whereas for al1 treatments. 37 patients (82.2%) responded. Age did not affect likelihood of response. whereas increasing duration of treatment and the additional use of analgesics were each negatively a 日 sociated wìth re? sponse. Aside from rare dizziness (n = 3) no side effects were noted. Conclusions: Intravenous valproate is a safe. rapid? ly effective. abortive headache agent. It appears to be an effectìve analgesic for status mìgraine. Key words , intravenous valp