低剂量PF方案持续注射治疗晚期肝癌的疗效观察.pdfVIP

肿瘤基础与临床 2oo8 年 12 月第 21 卷第 6 期 .487. 低剂量 PF 方案持续注射治疗晚期肝癌的疗效观察 裴志东，杨致远，薛琪 (艳阳市中心医院肿瘤内科，河南洛阳 471009) 摘要:目的 观察低剂量 PF 方案持续注射泊疗晚期原发性肝癌 (PHC) 的疗效和毒副反应。方法 70 例晚期 PHC 随机分为两组， 治疗组 36 例给予低剂量 PF 持续静脉注射方案 :DDP 3 mg/ (m2 .的， civ ， d_5/周 ;CF 100 mg ， civ ， d 1.J周 ;5-Fu 170 mg/( m2 • d) , civ ，6 句 8 h/d ， d_7/周，连用 3 周为 1 周期，至少完成 1 个周期或以上。对照组 34 例给予最佳支持治疗。结果 治疗组和对照组的 临床症状改善(即临床受益反应)有效率分别为 55.6% (20/36) 、 23.5% (8/34) ，差异有统计学意义 (P 0.01)，中位生存期均为 17. ∞周，治疗组的毒副反应可以耐受。结论 低剂量 PF 持续静脉注射方案治疗晚期 PHC ，毒副反应可耐受，可以提高生存质量， 但未延长生存期。 关键词:低剂量 PF 方案持续注射;晚期原发性肝癌;生存质量 中图分类号: R730. 53 ; R735. 7 文献标识码 :A 文章编号 :1673 -5412(2008)06 -0487 -03 Iρw-Dose Chemotherapy with Continuous Cisplatin and 5-FluorouraciI Infusion for Advanced Hepatocellular Carcinoma Pei Zhidong , Yang Zhiyuan , Xue Qi (Department 01 Oncology ， 加 Central Hospital 01 Lz品。晤，Lz町ang 471∞9 ， China) Abstrac:t:Objec:tive To inveøtigate the curative efficacy and toxicity of Iow-doøe chemotherapy with continuous ciøplatin and 5-fluorouraciI infusion for advanced hepatocellular carcinoma. Methods 70 patients with advanced hepatocelluIar carcinoma were divided randomly into two groups , 36 c国es in the trealment group received low-dose chemotherapy with continuous ciøplatin and 5-fluorouraciI infusion: ciøplatin 3 mg/ (m2 • 的， civ , days 1-5/w( in a week) ; CF 1∞ mg civ , days 1 ,4/w; 5-fluorouracill70 皿gi( 皿2. 的，巾，6-8νd ， daysl-7闭， one cycle for continuous 3 weeks , and patientø received for one cycle at least; 34 c剧创 in the contrasl group received the beøt supportive treat- ment. Results The clinical benefit respon回 rate was 55. 6% in the trealment group and 23.5% in the control group( P 0.01) , the medi- an survival time w田 all 17 weeks , the toxicity of the treatment group was mild. Conc:lusion Low-dose chemotherapy with continuouø ciøpla- tin and 5-fluorouracil infusion can improve the quality of life for advanced hepatocellular carcinoma , but the survivaltime w臼n t prolonged_ Key words: low-doøe chemotherapy wi由 continuous cisplat