比阿培南对医院常见感染菌的抗菌活性分析.pdfVIP

药学与1陷在研先 2酬年12 月 Pharmaceutical and Clinical 问esearch 2创渺， 17 (6) ·用药分析· 比阿培南对医院常见感染菌的抗菌活性分析 朱冰，汪璐，龚扬彬，邹自英 成都军区总医院检验科，成都 61∞83 摘 要 阔的:调查新药比阿培南对我院临床分离的常见致病茵的抗菌活性，为临床用药提供依据。方法: 收集我院临床分离的 135 株共7 类常见致病菌，采用 K-B 纸片琼脂扩散法，并设对照组:关罗培南组和亚滕络南 组，结果判定参照 NCCLS 2(览畅...标准。结果:135 株致病筒对比阿培尚的药物敏感率为 86.6% ，对照组:关罗 培南为49.6% 、~滕培均为46.2% 。比阿培均对铜绿假岛生I!.商和不动杆菌巍的敏感且在分别为 859毛和509岛，而美 罗培南为 50% 和20.8% ，亚膝培南为 40%和8.3% 。结论:新药比阿培南的抗菌活性明显高于同类破青t.烯类抗 生朵美罗培南和亚滕培1翁，尤其在对铜绿假单胞简和不动杆茵属细篱的敏感皮上，新药比阿生告南更具抗商活性。 关键诩 比阿培南;药物敏感;K-B 纸片扩散法 中图分类号 R915 文献标志明 A 文章编号 1673幡7806(2侃19 )06-495 -03 Sensitivity analysis of biapenem on common bacteria strains of hospital infection ZHU Bi吨. WANG Lu , GONG Yang-bin , ZOU Zi-ying 命neral Hospítal , Che，啄du Military COmT1Ul时， Che哺du 61∞83 ， Chirw Abstract Objective: To investigate the sensitivity of a new drug biapenem on common bacteria strains. Methods: The method of K-B paper dispersion w幽 used. Totally 135 strains , including 7 clas树s of spe- cies were sep唱rated. Evaluating standard was referred to the NCCLS-2以焰， and results were compared with meropenem and imipenem. Results: 四le sensitive rate of the pathogenic bacteria to biapenem Wi幽 86.6%. yet those to meropenem and impenem were 49.6% and 46.2% respectively. In addition , the sensitive ratesωbiapenem for P. αeruginosαandA. bαumannil were 85% and 50% , which were 40% and 8.3% to imipenem , and 50% and 20.8% to meropenem. Conclusions: Biapenem was more effec- tive than meropenem and imipenem. It is much sensitive to P. aeruginosa and A. baumannil especially. Keywords Biapenem; Drug sensitivity;ιB paper dispersion