Markers of myocardial injury in the diagnosis of acute myocardial infarction Value.doc

 PAGE \* MERGEFORMAT 12 Markers of myocardial injury in the diagnosis of acute myocardial infarction Value Of: Zhu Ke, Langbin barrier, Liu Wanqiong [Abstract] Objective To evaluate the markers of myocardial damage cardiac troponin I (cardiac troponin I, CTnI), creatine kinase isoenzyme (creatine kinase isoenzyme, CK MB) and high sensitive C-reactive protein (highsensitive C reactive protein, hs CRP) combined detection of acute myocardial infarction (acute myocardial infarction, AMI) diagnosis. approaches into the treatment complained of chest pain in 135 patients, measuring serum hospital 2h CTnI, CK MB, and hs CRP values #8203;#8203;to AMI indicators as recommended by WHO gold standard is divided into 88 cases of AMI group and non-AMI group 47 patients, a single variable and multiple covariates ROC curve analysis. Results (1) AMI group CTnI, CK MB, and hs CRP levels were significantly higher than non-AMI group, P lt;0.01 , (2) CTnI, CK MB, and hs CRP were three markers was significantly associated with AMI, Logistic regression probability of precipitation forecasting model integrated AMI: Log (P =- 6.006 +2.547 CTnI +1.569 CK MB +0.966 hs CRP, ( 3) CTnI the best sensitivity and specificity of 0.852 and 0.809, CK MB to 0.807 and 0.681, hs CRP was 0.716 and 0.638, 0.966, and integrated prediction probability 0.830, (4) ROC area under the curve followed by a comprehensive prediction probability ( 0.958gt; CTnI (0.878gt; CK MB (0.768gt; hs CRP (0.725, significant difference, P lt;0.01. Conclusion CTnI, CK MB, and hs CRP in the diagnosis AMI sensitive and specific biomarkers, combined detection of integrated indicators diagnostic performance was excellent in a single index. [Keywords:] acute myocardial infarction, cardiac troponin I, creatine kinase isoenzyme, high-sensitivity C-reactive protein, Logistic regression Acute myocardial infarction (acute myocardial infarction, AMI) is a serious acute hazard to human health in the heart, AMI’s early diagnos