Maternal serum folate homocysteine levels and risk of fetal neural tube defects of.doc

 PAGE \* MERGEFORMAT 16 Maternal serum folate homocysteine levels and risk of fetal neural tube defects of Study: Global English Wu Lihua Liu Ching-love [Abstract] Objective maternal serum folate and homocysteine #8203;#8203;(homocysteine, Hcy) levels and fetal neural tube defects (neural tube defects, NTDs) relationship. Methods A case-control study design to the high incidence of NTDs in Shanxi Province 5 County as a research site, this field study conducted in 9 hospitals and prenatal care or delivery of pregnant women agreed to participate in this study. means a patient group B fetal NTDs diagnosed as pregnant and pregnant women diagnosed through the termination of pregnancy and live / dead fetuses of pregnant women produce NTDs. refers to the control group randomly selected hospitals in the same local normal pregnant women. detected in all subjects serum levels of folate and Hcy, compared the case group and control group differences in serum folate and Hcy levels. were in the control group serum folate and Hcy levels of 10 and 90 percentile as the cutoff value, comparing groups of different levels of the risk of NTDs. The results meet the requirements of the cases collected 113 cases, 148 cases of controls. cases and controls, serum folate levels were 10.5 (4.4 ~ 24.5) nmol / L, 12.9 (6.3 ~ 32.7) nmol / L, 2 group, the difference was statistically significant (P = 0.001), 2 serum Hcy concentration, the difference was not significant (Pgt; 0.05); case classification and found that children without brain pregnancy and spina bifida in the maternal serum folate levels than the control group, the difference was statistically significant (P lt;0.05), pregnancy, maternal serum folate encephalocele average lower than the control group, but no significant difference (Pgt; 0.05), pregnancy, pregnant women with no brains of children with higher Hcy levels, the difference was statistically significant (P lt;0.05); NTDs pregnant women with low folate levels signi