Matrine on the protective effect of kidney of diabetic rats.doc

 PAGE \* MERGEFORMAT 14 Matrine on the protective effect of kidney of diabetic rats Of: Fusong Bo Tang Xulei Jiali Yun Qiao Chengdong Ma Zhiyuan Abstract Objective matrine on diabetes (DM) renal protective effect and its mechanism. Methods unilateral nephrectomy and intraperitoneal injection of streptozotocin induced diabetic nephropathy (DN) rats and normal control (NC) group; DN control (DN) group, matrine treatment group (MT) (100 mg kg-1 d-1), intraperitoneal injection the rats were sacrificed after 8 w, DM detection of matrine on the impact of renal function, pathological HE staining to observe pathological changes and immunohistochemical detection of renal transforming growth factor 1 (TGF 1) expression. Results compared with NC group, DN group increased urinary protein excretion, glomerular volume increased, blood urea nitrogen (BUN) and creatinine (Cr) increased expression of renal TGF 1 increased (P lt;0.01) . DN matrine significantly reduced urinary protein excretion, lower serum BUN, Cr level (P lt;0.05, P lt;0.01), glomerular volume was significantly improved renal TGF 1 expression was significantly lower (P lt;0.05, P lt;0.01). Conclusion matrine inhibited significantly improved the expression of renal TGF 1, improve glomerular hypertrophy, reduce proteinuria, and renal injury in rats with DM rats. Keywords: matrine; diabetic nephropathy; transforming growth factor 1 (TGF 1) Matrine (matrine) have a clear role against hepatic fibrosis, in the treatment of chronic hepatitis and liver fibrosis, has been widely used. Tang Suyang matrine and other studies confirmed the skin fibroblasts also inhibited the activity of 1; Fu Songquan so that matrine on pulmonary fibrosis have a good therapeutic effect 2, but for diabetic nephropathy (DN ) The role of domestic rarely reported. We examined the effects of transforming growth factor 1 (TGF 1) in the DN expression in rat kidney and renal structural and functional changes the relations