Mechanical ventilation induced lung injury biomarkers Progress.doc

 PAGE \* MERGEFORMAT 15 Mechanical ventilation induced lung injury biomarkers Progress [Abstract] for acute lung injury (acute lung injury, ALI), acute respiratory distress syndrome (acute respiratory distress syndrome, ARDS) patients, although positive pressure ventilation can save lives, but now commonly used in clinical tidal volume, PEEP and airway plateau pressure ventilation and other programs but it will lead to lung injury patients, and the degree of lung injury, a significant impact on prognosis and mortality. In recent years, the innate immune response and inflammatory reaction in the mechanical ventilation induced lung injury (ventilator-induced lung injury, VILI) role in the pathogenesis of attention and has been widely studied, and the formation of the inflammatory response is the major mechanism of VILI, and plasma, serum and bronchoalveolar lavage fluid cytokines and the chemokine is VILI’s main biological markers of academic point of view. In this paper, the results of recent studies, focuses on biological markers of VILI progress. [Key Words] mechanical ventilation; lung injury; VILI; inflammatory reaction; biological markers [Abstract] For patients with ALI (acute lung injury) or ARDS (acute respiratory distress syndrome), the positive pressure mechanical ventilation can save their lives. However, a lot of experimental studies and clinical data have proved that how the ventilatory strategies (including the tidal volume, the positive end-expiratory pressure and the plateau airway pressure, etc) can affect the severity of the lung injury, the outcomes and the mortality. In recent years, the effects of the inherent immunity and the inflammation have been widely studied in pathophysiology of the ventilator-induced lung injury (VILI). The investigators find that the inflammation is the main mechanism in VILI and the cytokines and chemokines are the main biological markers in plasm, serum and bronchoalveolar lavage fluid. This review will f