Mechanism of radiosensitization Progress.docVIP

 PAGE \* MERGEFORMAT 15 Mechanism of radiosensitization Progress [Keywords:] tumor radiosensitization Some 70% of the tumors require radiation therapy, but most of all have some tumor resistance to radiation, even in the precise radiotherapy dominant today, the clinical recurrence of the situation within the radiation field is still there. So as radiosensitizer research focus in recent years, but the mechanism of radiosensitization for sensitizer because of its clinical application and research and development of new drugs to provide a theoretical basis for the concern. now the mechanism of radiosensitization related research are summarized below . 1 by increasing the radiation damage of tumor cells play a primary role in sensitizing Ionizing radiation can cause DNA protein crosslinks, DNA single-strand breaks (SSB), DNA double-strand break (DSB), base damage or loss and other damage. Which is the most important lethal DSB damage. Increase the target cells to ionizing radiation primary injury caused by, OwenTaverna [1] such that 5 2 deoxyuridine iodine acid (Idurd) DNA binding and inhibition of DNA base excision repair, induction of DNA single strand breaks, while increasing the DNA double-strand breaks [2]. There studies have shown that after irradiation by double-strand break repair tissue testing to predict the radiation sensitivity [3] .1963 of Adams’s “pro-electron theory” that the nitroimidazole compounds to target molecules by free genetic radiation injury can not re- affect access to electronic repair, and then, with a high electron affinity of hypoxic cell sensitizer, a research focus, after a modified chemical structure of the 2nd generation of parents have e-sensitizer according to his nitrate yl (etanidazole, ETA) [4, 5], Shaner yl (san ~ ole, AK 2123) [6] and Nemo yl [7], in which Shaner azole toxicity in normal tissues without increasing significantly improved the case of the radiosensitivity of cervical cancer Ⅲ [8 ]. nimodipine yl ra