Matrine Progress eye disease prevention.doc

 PAGE \* MERGEFORMAT 11 Matrine Progress eye disease prevention [Abstract] Sophora and other legumes matrine is the main active ingredients, pharmacological effects of a wide clinical application in general. In recent years, prevention and treatment of matrine in the clinical application of eye disease conducted in-depth research, it has anti- inflammation, anti-fibrosis, inhibition of tumor growth and other effects and treatment efficacy is good. In this paper, matrine in the prevention of several common eye diseases, advances in basic research do a review. [Keywords:] matrine; Eye disease; Prevention Matrine (Matrine, Mat), chemical formula C15H24N2O, molecular weight 248.36, is the root of Sophora plants herbs, plants, fruit and other organic solvent extraction with ethanol made from alkaloids. It is a large number of pharmacological studies and Show Matrine clinical liver fibrosis, anti-arrhythmic, anti-inflammatory, anti-hypertensive vascular remodeling, anti-tumor and immune suppression, and other pharmacological effects [1]. Mat the value in the fight against eye disease is still in the experimental research stage, but according to its broad pharmacological effects, could be used for a variety of eye diseases, the prevention and treatment. 1 matrine and ocular inflammation 1. 1 Mat and Mat inflammatory eye infection can significantly against a variety of acute exudative inflammation of the eye. Previous studies found that Mat for peritonitis, skin inflammation, treatment of fatal hepatitis. Its therapeutic mechanism of action: one direct inhibition macrophage secretion of TNF, IL-1 and IL-6 inflammatory cytokines [2-4]; the other hand, decreased by blocking calcium in neutrophils Ca2 + ion concentration, inhibition of PLA2 activity, the release of inflammatory mediators [5] ; In addition, it also inhibits the substance P receptor expression thereby reducing the generation of inflammatory mediators [6]. 1. 2 Mat normal cornea with ker