Matrine Preparation of sustained-release tablets and release rate of.doc

 PAGE \* MERGEFORMAT 7 Matrine Preparation of sustained-release tablets and release rate of [Abstract] Objective To prepare the sustained-release tablets of matrine and investigate its dissolution. Methods hydroxypropyl methyl cellulose and ethyl cellulose as the matrix material was prepared by one days matrine administration two times a sustained-release tablets, and the cumulative release rate measured in vitro. The results of matrine in vitro release curve of sustained-release tablets in line with Higuchi equation, r = 0.999 0. Conclusion The technique is simple and feasible sustained-release tablets, sustained-release evident result. [Keywords:] matrine sustained-release tablets; Release; Preparation; Higuchi equation Abstract: Objective To prepare matrine sustained  release tablets and evaluate its release characteristics. Methods The matrine sustained  release tablets was prepared with HPMC and EC. The release rate of sustained  release tablets was tested by HPLC method. Results The release curve of matrine sustained  release tablets conformed to Higuchi formula, with r = 0.999 0. Conclusion The method was simple and feasible, and the product had obvious sustained  release effects. Keywords:: matrine sustained  release tablets; release rate; Higuchi formula Matrine from Sophora Sophora alopecuroides leguminous plants, such as broad bean root isolated inside the four-ring of the quinolone alkaloids. Inhibit the replication of its hepatitis B HbeAg to improve hepatitis symptoms and pathological signs, anti-cancer, anti-arrhythmia, anti-hepatic fibrosis, immune suppression, anti-inflammatory, anti-hypertensive vascular remodeling and other pharmacological effects [1]. Preparations for clinical use of matrine injection-based, its elimination half-life is only 76 min, if made of ordinary tablets, the daily oral administration of 3 to 4 times the need to give treatment and patient inconvenience. For the convenience of patients with medication,