Matrix metalloproteinase and its application in primary open-angle glaucoma the role of research.doc

 PAGE \* MERGEFORMAT 27 Matrix metalloproteinase and its application in primary open-angle glaucoma the role of research Abstract of matrix metalloproteinase (MMP) are a class of endogenous zinc-dependent protease family, the main function is to degrade the extracellular matrix (ECM) and basement membrane. In recent years, the people of the MMP of the structure, function, regulation of activity and in primary open-angle glaucoma pathogenesis and treatment of the role of an initial understanding. In this paper, the results of research in this area are reviewed. Keywords: matrix metalloproteinase; primary open-angle glaucoma; extracellular matrix Primary open-angle glaucoma (POAG) is a common one of blinding eye disease, to date, its etiology and pathogenesis is not clear. Trabecular meshwork organization to change the dynamic balance of ECM and MMP increasingly primary open-angle glaucoma research attention of scholars. This paper studies the relationship between MMP and the progress of POAG are summarized below. 1 MMP structure and classification of MMP is a class of endogenous zinc-dependent proteolytic enzymes, the main function is to degrade ECM and basement membrane, in addition, in many physiological and pathological processes play an important role, for example, the degradation of basement membrane, ECM of the refactoring, connective tissue of the update, the occurrence of blood vessels, regeneration, wound repair, tumor progression and metastasis. MMP family in humans has been found that several members of the 20 new members also continue to be discovered. According to their substrate specificity and can be divided into five categories [1]: (1), collagenase, including fibroblasts, macrophages, epithelial cell-derived collagenase MMP-1, obtained from leukocyte collagenase MMP-8, MMP-13 and MMP-18. Substrate hydrolysis is the major collagen fibers, such as the Ⅰ, Ⅱ, Ⅲ, Ⅶ collagen and basement me