Medical interventions for myocardial fibrosis in experimental research.doc

 PAGE \* MERGEFORMAT 3 Medical interventions for myocardial fibrosis in experimental research [Keywords:] Myocardial fibrosis; traditional Chinese medicine; experimental studies; Review Myocardial fibrosis (MF) are cardiovascular disease, an important pathological changes. For the long-term shortage of blood supply to the heart muscle, myocardial histogenesis dystrophy and atrophy, or large area of myocardial infarction, as well as the organizational structure of the normal myocardium excessive accumulation of collagen fibers and collagen were significantly higher or collagen change. The clinical features of the heart gradually expanded, arrhythmia and heart failure. Is a Chinese medicine ‘palpitations’, ‘palpitation’, ‘Chest’, ‘Tan Yin’ well being. This pathological process is a view to cardiac decompensation by compensatory changes in the critical period, which subsided restore myocardial tissue and stroma balance between, so that a gradual softening of the rigid level is conducive to the improvement of cardiac function. Therefore, how to prevention and treatment of myocardial fibrosis is currently the focus of medical research and hot. In recent years, medical interventions for myocardial fibrosis made gratifying achievements. Are summarized below. A single taste of Chinese medicine or Chinese medicine extract 1.1 Salvia Sun Alliance Equality [1] observation of Danshen on left ventricular hypertrophy in spontaneously hypertensive rats and its effects on myocardial fibrosis in a deterrent effect. The results showed that left ventricular mass index Salvia can, myocardial cell diameter, area, myocardial collagen volume ratio of perivascular collagen area and lumen area ratio, Ⅰ and Ⅲ collagen content, Ⅰ / Ⅲ collagen ratio decreased significantly, indicating Salvia with the prevention and reversal of left ventricular hypertrophy in hypertensive rats, the formation and reversal of myocardial fibrosis. Tang Zhongzhi, etc. [2,3] of Danshen in spontaneously