Medical Thesis Fan - auditory neuropathy.docVIP

 PAGE \* MERGEFORMAT 20 Medical Thesis Fan - auditory neuropathy Auditory neuropathy (auditory neuropathy, AN) is increasingly being recognized in recent years, a kind of special clinical manifestation of hearing impairment, its diagnosis and treatment are different from the normal sensorineural hearing loss. Worthington et al [1] in 1980 reported 4 cases, they have can be measured by pure-tone hearing thresholds, but was absent auditory brainstem response (auditory brainstem response, ABR). Since then, scholars have reported similar cases [2,3], where Kraus et al [3] first noted that the speech recognition rate of these patients disproportionately lower than the pure tone threshold, then further found that these patients evoked potentials and cochlear microphonic otoacoustic emissions were normal. 1993, Berlin et al [4] first found in 2 patients evoked otoacoustic emission suppression of the disappeared, and proposed a ‘Ⅰ -type afferent neuron disease’ concept. 1996, Starr et al [5] for the first time named auditory neuropathy in 1998, Doyle et al [6] reported eight cases of children with auditory neuropathy. Such lesions show also attracted the concern of Chinese scholars, GU Rui et al [7] in 1992 reported 16 cases of central low-tone sensorineural hearing loss, according to hearing the results of electrophysiological examination should be consistent with auditory neuropathy in some patients diagnosis; 1999 Leung Fung, and so on [8] reported 17 cases. Clinical features A lower incidence of auditory neuropathy, and many childhood years of onset. 1999, Rance et al [9] In 5199 cases of neonatal period are risk factors for hearing impairment in infants and young children and adolescents ABR abnormalities detected in 109 cases, of which 12 cases was absent ABR, but the microphonic potential of the normal, that is, auditory neuropathy In this group of high-risk infants and young children, the incidence rate of about 0.23%. Starr et al [5] reported 10 cases of ad