Mechanism of liver fibrosis research.doc

 PAGE \* MERGEFORMAT 7 Mechanism of liver fibrosis research Keywords In recent years, hepatitis, cirrhosis of the research on the pathogenesis have made great progress, especially in the liver extracellular matrix research, collagen fiber synthesis (fibrogenesis) and fiber dissolution (fibrogenolysis) to maintain homeostasis, such as enzymes and collagen synthesis phase against a variety of matrix metalloproteinases (matrixmetalloproteinnase, mMP) and the inhibition of secretion mMP enzyme tissue inhibitor of metalloproteinase (tIMP) and so on. These studies not only the detection of liver fibrosis in a variety of ways to further the use of collagen in animal experiments synthase antagonist, antibody and the collagen synthesis in the enzyme mRNA to gene therapy and other exploration. However, liver fibrosis and fibrosis in other parts of the body, like, were considered to be the body of a repair of the damage, even if you can use gene therapy or other methods may be the total elimination of fibrosis, but the human body to inhibit or eliminate fibrosis after and consequences of what the reaction has not yet any experiment can be predicted, it is in this case in recent years, the mechanism of liver fibrosis have conducted in-depth discussion [1]. 1, liver fibrosis the liver three basic phenomena Hepatitis, hepatic fibrosis is generally considered the cause of liver cell necrosis and apoptosis caused by, is tissue necrosis, apoptosis, when blood platelets can promote the release of the fibrosis factor the role of platelet-derived growth factor (platetetderivedgrowthfactor, pDGF) caused. However, in other tissue injury occurs when the blood flow is also pDGF, but no liver fibrosis, indicating pDGF may not be the main reason for liver fibrosis. Liver fibrosis occurs when there are three basic phenomena that merit our attention: (1) an increase in liver extracellular matrix; (2) stellate cells into myofibroblasts; (3) the cytoplasm of stellate cells, retinol dec