Mechanism of orexin relationship with general anesthesia.doc

 PAGE \* MERGEFORMAT 21 Mechanism of orexin relationship with general anesthesia [Abstract] orexin and its receptors on the structure, distribution and related regulatory role in the introduction, lists the primary role of orexin, including the regulation of feeding, drinking behaviors, sleep-wake cycle, energy metabolism, and the autonomic nervous system regulation, etc., and based on the current general anesthesia on the orexin system and related research results were discussed in depth. [Keywords:] orexin, orexin receptor, general anesthesia [Abstract] In this view, we introduce the structure and distribution of orexin and its receptors, and those factors involved in modulating the effects of orexin and its receptors.The main effects of influences that orexin on feeding behavior, sleep / wakefulness states, emotion , reward, and energy homeostasis and autonomic nervous system are discussed and the mechanisms by which orexin regulates general anaesthesia are also focused on. [Keywords:] orexins, orexins receptor, general anaesthesia In 1999, Japanese scholars Yanigasawa research team led by brain and orphans in finding G (orphan G protein receptor ligand combination of the two found by the lateral hypothalamus (lateral hypothalamic area, LHA with the synthesis and secretion ingestion of small molecules to promote neural peptides, named orexin A (orexin A, OXA and orexin B (orexin B, OXB. orexin with the orphan G protein conjugate receptor ligands, the Chinese translation with orexin, orexin, orexin, orexin hormone, increased food and other factors. In recent years, studies have shown that orexin feeding not only can promote the role of such control of feeding behavior, but also involved in regulating sleep-wake cycle, energy metabolism, as well as heart vascular and autonomic nervous system regulation, and the role of .2008 Kelz’s team found that orexin system in general anesthesia wake up, therefore, the orexin relationship with general anesth