Melatonin on rats with chronic stress depression in cerebral cortex BDNF TrkB expression and cognitive behavior.doc

 PAGE \* MERGEFORMAT 15 Melatonin on rats with chronic stress depression in cerebral cortex BDNF TrkB expression and cognitive behavior OF: David Zhang, Hao Xu Qin, Chen Yan, Xu Qing, Zhang Ye, Xu Jin, Zhou Zhiqiang, Liu Yiren, Di Rongke [Abstract] Objective: To investigate the chronic stress on cognitive behavioral change and cerebral cortex BDNF, TrkB expression, the antidepressant effect of melatonin and its mechanism. Methods: 60 SD rats were divided into 5 groups: control group, model group, melatonin treatment of ~ group, 12 in each group. by chronic unpredictable mild stress and depression alone model dependent methods produced by intraperitoneal injection of melatonin to intervene to “T”-type maze test and the opening test before and after observational study learning and memory abilities and exploratory behavior changes, determined by immunohistochemistry in cerebral cortex BDNF, TrkB expression. Results: The stress stimulation, “T” type maze test in the model number of errors than the control group, the control group (P lt;0.01, and melatonin treatment group (P lt;0.01, the opening test of the model level and vertical control group than the control group the number of activities (P lt;0.01 and melatonin treatment group (P lt;0.01 / P lt;0.05. forebrain cortex can be seen at all levels BDNF, TrkB positive cells, model and gray positive cells in the control group than the control group and melatonin treatment group (P lt;0.05 / P lt;0.01, melatonin treatment group than the control group (P lt;0.01. Conclusion: Melatonin can be effective in promoting the expression of cerebral cortex neurons of BDNF, TrkB, speculated that melatonin may be adopted Enhanced neurotrophin, which play a role in inhibiting onset of depression. [Keywords:] depression; melatonin; chronic mild stress; brain-derived neurotrophic factor; tyrosine kinase B [Abstract] Objective: To explore the anti depression effect and its mechanism of melatonin (MT), the changes of co