Mesangial cells from the phenotype of Chinese Medicine Mechanism of Thought diabetic nephropathy_0.doc

 PAGE \* MERGEFORMAT 12 Mesangial cells from the phenotype of Chinese Medicine Mechanism of Thought diabetic nephropathy [Keywords:] mesangial cells phenotype in diabetic medicine For diabetic nephropathy (DN) of the occurrence and development mechanism, although modern medical research to date has been involved in many aspects, such as protein non-enzymatic glycation of glomerular hemodynamic changes, a variety of growth factors / the role of cytokines But every single mechanism can not explain the development of DN the whole picture. In Chinese medicine, although clinical and experimental studies have shown that some active ingredients of Chinese herbal formula or the role of potential control DN, but the mechanism of Chinese medicine control DN lack of in-depth research, so in terms of medicine in the prevention and treatment difficult to promote the use of DN. As Chinese medicine, especially traditional Chinese medicine complex composition, and its efficacy is the result of multi-target interaction, while the current study the role of multiple channels from a single attempt to elaborate the mechanism of Chinese medicine, this study the role of ideas inconsistent with the characteristics of traditional Chinese medicine, it is difficult to highlight the advantages of Chinese medicine. Thus, the DN for the prevention and treatment mechanism of Chinese medicine research, how to choose the starting point will be the key. modern medical research found that, DN exists mesangial cells (MC) phenotype conversion, showing hypertrophy of mesangial cells, embryonic flag @ - smooth muscle actin (@-SMA) in the abnormal expression of extracellular matrix ( ECM) a large number of secretion. MC’s phenotype may be the gradual accumulation of glomerular ECM, eventually leading to the cellular basis of glomerular sclerosis. MC phenotype regulation is the interaction of many risk factors the results. Therefore, the study Herbs on the role of MC phenotype and its mechanism