Mesenchymal stem cells in hematopoietic regulation role of.doc

 PAGE \* MERGEFORMAT 28 Mesenchymal stem cells in hematopoietic regulation role of Abstract mesenchymal stem cells (MSC) as the hematopoietic microenvironment major source of cellular components, with self-renewal and multilineage differentiation potential of hematopoietic cells through direct contact, secretion of extracellular matrix and various cytokines in the maintenance of hematopoietic microenvironment the integrity of the structure and function, thereby achieving the fine regulation of hematopoiesis. In this paper, at home and abroad in recent years MSC’s research on the MSC’s role in hematopoietic regulation, such as the MSC to support hematopoietic cells secrete a variety of factors, MSC interaction between expression and hematopoietic cell adhesion molecules, the joint MSC transplantation on hematopoietic reconstitution supporting role in its clinical application are reviewed. Keywords: mesenchymal stem cells, Mesenchymal Stem Cells in Hematopoietic Regulation - Review Abstract As the progenitor of most cell components in the hematopoietic microenviroment, mesenchymal stem cells (MSC) exhibit self-renewal and multilineage differentiation capacity. Through direct interaction with hematopoietic cells, secreting extracellular matrix and factors, MSC maintain the integrity of hematopoietic microenvironment and regulate hematopoiesis accurately. This review summarized the function of MSC in hematopoietic regulation, such as secretion of cytokines supporting hematopoiesis, MSC expression and adhesion molecules interacting with hematopoietic cells, and supportive effects of transplantation combining MSC with HSC on hematopoietic reconstraction, and its clinical perspectives. Keywords: mesenchymal stem cell; hematopoietic regulation; hematopoietic microenvironment Mesenchymal stem cells (mesenchymal stem cell, MSC) is closely watched for a class of multi-directional differentiation potential of stem cells. Fried