Mesenchymal stem cells in hematopoietic stem cell transplantation in the treatment of refractory were severe aplastic anemia and 2 cases of observation.docVIP

 PAGE \* MERGEFORMAT 15 Mesenchymal stem cells in hematopoietic stem cell transplantation in the treatment of refractory were severe aplastic anemia and 2 cases of observation Of: Ma Huizhen, Li Ning, Song Yongping, Wei Xudong, the Housing Bai Jun [Abstract] Objective To observe haploidentical mesenchymal stem cells (mesenchymal stem cells, MSC) combined hematopoietic stem cells (hematopoietic stem cells, HSC) were transplantation for treatment of 2 patients with refractory severe aplastic anemia patients (severe aplastic anemia, SAA) of the effect. Methods for the first time or 2 times in 2 cases of recurrence after transplantation in children with refractory SAA fat line haploidentical mesenchymal stem cells (adipose tissue derived mesenchymal stem cells, AMSC) United compatriots HLA matched peripheral blood stem cells all A total of transplantation. Results 2 patients had successful transplantation. two years in children in good condition, without giving any other treatment, no blood transfusion dependent. Conclusion MSC and HSC transplantation may increase the total of hematopoietic stem cell transplantation for treatment of intractable transplant success rate of SAA . [Keywords:] severe aplastic anemia; of hematopoietic stem cell transplantation; implant failure; mesenchymal stem cells In the past 20 years, hematopoietic stem cell transplantation (hematopoietic stem cell transplantation, HSCT) patients with severe aplastic anemia (severe aplastic anemia, SAA) in patients have been greatly improved efficacy [1]. But more retrospective data showed that graft failure is still a serious threat to one of the complications of life of patients. In animal experiments and human experiments have demonstrated that mesenchymal stem cells (mesenchymal stem cells, MSC) can promote hematopoietic stem cell (hematopoietic stem cells, HSC) of the plant into [27]. In addition, a large number of findings suggest, MSC on allogeneic lymphocytes can change the reacti