Mesenchymal stem cells transplantation regulation mechanism of immune effector cell research.doc

 PAGE \* MERGEFORMAT 24 Mesenchymal stem cells transplantation regulation mechanism of immune effector cell research Abstract mesenchymal stem cells (MSC) is a class with a high degree of self-renewal and multilineage differentiation potential of adult stem cells, because of low immunogenicity and allogeneic lymphocytes activated immune inhibition, and its migration immunity play an important role, but the exact mechanism has not been clear, this paper MSC regulation of the transplanted immune cells, such as the MSC transplantation in the role of immune regulation, MSC on the regulation of cell-mediated immunity (cell-cell direct contact, apoptosis, and MSC on lymphocyte adjustment mechanism), MSC immunomodulatory effects on DC and the MSC on the role of NK cells in immune regulation, etc. The results are summarized. Keywords: mesenchymal stem cells, Regulation Mechamion of Mesenchymal Stem Cells to Immuno-effector Cells - Review Abstract Mesenchymal stem cells have two main properties: self renewal and the ability to differentiate multiple lineage. Because MSCs exhibit low immunogenicity and demonstrate significant suppressive activity in cell cultures containing alloreactive T cells, they play an important role in transplantation immunology, but the exact mechanism remains unknown. This article focuses on the immunoregulatoty feature of MSCs to immunoeffector cells, such as T cells, B cells, and NK cells. The role of MSC in transplantation immunoregulation, regulatory mechanism of MSC in cellular immunity (direct contact of cells with cells , apoptosis and immunoregulation of MSC on lymphocytes), immunoregulation of MSC on DC and NK cells were reviewed. Keywords: MSC; immunoregulation; immuoeffector cell Mesenchymal stem cells (mesenchymal stem cells, MSC) is a highly self-renewal and multilineage differentiation potential of adult stem cells in different induction conditions, differentiate into a variety of tissue c