Mesylate Pazufloxacin Gel Preparation and Quality Control.doc

 PAGE \* MERGEFORMAT 9 Mesylate Pazufloxacin Gel Preparation and Quality Control Author: Chen Jianhua Li Jinwei Tan Yi Xi-Kui Ho [Abstract] Objective: To prepare mesylate Pazufloxacin gel, the establishment of quality control methods. Methods: Preparation of Carbopol 934 gels as a substrate, using high-performance liquid chromatography Mesylate Pazufloxacin content, and examine its stability. Results: The mesylate Pazufloxacin linear range of 20.0 ~ 80.0μ g * mL-1 (r = 0.9999), the average recovery was 98.1%, RSD = 1.77% (n = 6), gel was stable. Conclusion: The prescription of reasonable design, quality control method is accurate and reliable, preparation and good stability. [Keywords:] pazufloxacin mesylate gel preparation of quality control Pazufloxacin mesylate by Japanese research and development of new antibacterial fluoride incite Snow ketones, for Pazufloxacin the mesylate, with a broad spectrum anti-bacterial, anti-bacterial activity of high, side effects and tolerance and good characteristics [1,2]. Its by inhibiting the bacterial DNA topoisomerase Ⅰ and Ⅳ activity, inhibit bacterial DNA synthesis, resulting in the death of bacteria of clinical for the treatment of Gram-positive bacteria and-negative bacteria causing respiratory tract infections, urinary and reproductive system infections, skin and soft tissue infections and surgical infection [3]. At present the domestic market only injection, we have developed the basis of clinical need pazufloxacin mesylate gel. An instrument and reagent Agilent 1100 series high-performance liquid chromatography ,7312-1 electric mixer (Beijing amp;amp; Poor’s analysis of General Instrument Co., Ltd.), PHB-1 Portable pH meter (TriTrust companies); mesylate Pazufloxacin raw materials (Zhejiang stellite Pharmaceutical Co., Ltd., batch number: 20,061,106), mesylate Pazufloxacin reference substance (content 99.9%, Jiangsu Yabang Pharmaceutical Co., Ltd.), Carbomer 934 (UK Googrich companies); other accessories