Metabolic kinetics of volatile organic compounds in research and application of.doc

 PAGE \* MERGEFORMAT 14 Metabolic kinetics of volatile organic compounds in research and application of Keywords:: volatile organic compounds pharmacokinetics 1. Descriptive method of research and application: Over the past ten years, the pharmacokinetics of volatile organic compounds (pharmacokinetics or toxicokinetics) of the research work has made great progress, it is the application of kinetic theory to describe the organisms to volatile organic compounds ( volatile organic compounds referred to as VOCs) absorption, distribution, metabolism, and excretion of this complex process of science [1]. Among them, a descriptive approach is by measuring the different times post-exposure animal or human biological materials in the target compound and its metabolites concentrations and pharmacokinetic parameters with the description of the target compounds in order to study the dynamic process approach. For example, Green et al [2] studies have shown that PCE (PCE) metabolites of trichloroacetic acid (TCA). It also confirmed that rats and mice when the PCE to 293.13 mg/m3 inhalation, 3 hours after exposure of mice to reach peak blood TCA concentration (Cmax) of approximately 130 mg / L, while the rat blood Cmax was only 7 mg / L. Thus, mice conversion capability is obviously higher than PCE in rats. In addition, PCE-induced liver cancer in mice the effect of obvious, it is speculated that may be related to PCE in mice exposed to blood levels were significantly higher than rats on TCA. Korn et al [3] study confirmed that metabolites of styrene 7,8 - oxide-styrene (abbreviated SO). Nakajima et al [4] studies suggest that styrene in the liver by the cytochrome P450 enzyme system CyP2B6, CyP2E1 and CyP1A2 generated under SO. To-Figueras et al [5] studies have shown that hexachlorobenzene (HCB) as a major urinary metabolite of pentachlorophenol (PCP), and mercapto-PeCB (PCBT), and has proved to HCB in blood than the blood associated with the PCBT HCB and PCP in the corr