Metabolomics in the Study of Traditional Chinese Medicine.doc

 PAGE \* MERGEFORMAT 26 Metabolomics in the Study of Traditional Chinese Medicine Of: Zouzhong Jie, Yuan by the right, dream Juan Gong, Chen Zhibin [Keywords:] metabonomics; traditional Chinese medicine research; application Human understanding of complex life forms follow from the organ / tissue, cell-to-gene approach, and now back to study the characteristics of a holistic systems biology (system Biology) era, the distinctive characteristics of a variety of “group Science “(-omics) study of prosperity. metabolomics (metabonomics) is the second genomics (genomics), transcriptional genomics (transcriptomics) and proteomics (proteomics) of a group of school after the new approach is systems biology an important part, by Nicholson was first proposed in 1999 [1]. metabolomics core idea is to use modern technology for the quantitative determination of biological fluids (such as urine, plasma, tissue extracts, etc.) in the endogenous metabolites to study organisms in different states (physiological and pathological conditions, before and after administration, etc.) changes its metabolites, metabolite map through direct knowledge of the overall analysis of pathophysiological and biochemical status, combined with chemical information analysis method to determine the source metabolites of small molecular components of change patterns, to obtain the corresponding group of biomarkers (biomarkers), characterized by, or reveal the organism at a specific time, under the overall functional status [1,2]. subsequently appeared for the plants Metabonomics (metabolomics) [3]. Now metabonomics in drug toxicity and safety evaluation, difficult diagnosis, drug development and drug mechanism of action research in many fields of life sciences shows the broad application prospects [4 , 5]. Complete metabolomics analysis process should include sample collection, pretreatment, instrumental analysis and identification, data analysis and interpretation of biomarkers sense, the