Milk clean Capsules Toxicology Study.doc

 PAGE \* MERGEFORMAT 10 Milk clean Capsules Toxicology Study Author: Yan-yan Yang Fa Chen Chao Song Xing-Fu Huang Ji [Abstract] Objective To observe the milk-cleaning capsule acute and chronic toxicity. Methods The acute oral toxicity and long-term toxicity of law. The results of acute toxicity test in mice fed the maximum tolerated dose administered on a human clinical dosage of 160 times. The long-term toxicity test milk Trojan capsules each dose group no significant abnormal changes in the indicators. Conclusion milk Trojan capsule dosage formulation, approach and course of treatment in clinical application is safe. [Keywords:] Milk-cleaning capsule long-term toxicity Acute Toxicity Abstract: ObjectiveTo study the acute and chronic toxicity of Rujiean Capsule. MethodsAcute and chronic toxicological methods were carried out by oral administration.ResultsIn the experiment of acute toxicity, the maximum tolerance dosage by gavage in mice was 160 times of the clinical dosage in humans. The chronic toxicity experiment didn’t show significant changes in the examination items of rats in every Rujiean dosage group. ConclusionRujiean capsule is safe to be used in clinical practice and had no acute and chronic toxicity. Keywords:: Rujiean Capsule; Acute Toxicity; Chronic toxicity Milk Trojan capsule is angelica, red sage root, Bupleurum and so the composition of compound preparation of traditional Chinese medicine, with blood circulation Huayu, Ruanjian Sanjie such as efficacy, in clinical practice for the treatment of hyperplasia of mammary glands obtained good effect. In this study, pairs of clean milk safety capsule toxicological evaluation carried out. 1 Materials and equipment 1.1 Animals Kunming mice, female (18 ~ 22) g. Female is not pregnant SD rats, of clean grade, weight (200 ± 20) g (analgesic experiments), (100 ± 20) g (long-term toxicity test), from Huazhong University of Science and Technology Division of Experimental Animal, Tongji Medical C