Money Grass flavonoids extract antithrombotic effect of.doc

 PAGE \* MERGEFORMAT 4 Money Grass flavonoids extract antithrombotic effect of [Abstract] Objective: To observe the Money Grass flavonoids extract on rats in vivo thrombosis and platelet aggregation rate. Methods: The production model of venous thrombosis in rats to observe the thrombus wet weight; use of ADP-induced rat platelet aggregation, platelet aggregation rates at different times and maximum aggregation rate. Results: The Money Grass flavonoids extract 30,20 mg.kg groups are to varying degrees, inhibit the formation of venous thrombosis in rats, reducing thrombus wet weight and dry weight; inhibit ADP-induced platelet aggregation at different time points and Maximum aggregation rate. Conclusion: The Money Grass extract flavonoids can significantly against the formation of thrombus, and has significantly reduced the role of platelet aggregation. [Keywords:] Money Grass flavonoids; anti-thrombosis; platelet aggregation; mice Money Grass for Primula plants of Lysimachia (Lysinmachia christi-nae Hance) dry the whole plant, alias ‘Huo Xue Dan’, the main chemical constituents of flavonoids, including: quercetin (quercetin), quercetin -3-0 - glucoside, kaempferol (kaempferol), and kaempferol, and so on. In recent years, studies have shown that money grass flavonoids can significantly improve myocardial nutritional blood flow, reducing myocardial ischemia and injury, and similar to the role of dipyridamole. Thrombosis in this experiment by measuring the body weight and platelet aggregation rate to explore the role of its anti-thrombotic mechanism for the development and application of the drug prevention and treatment of thrombotic diseases provide some scientific basis. 1 on the impact of thrombosis in rats 1.1 Experimental Methods 50 selected Waster rats, weighing 200 ~ 250g, male and female in half, from the Changchun High-Tech Research Center Medical animals were randomly divided into blank control group, positive control group, Money Grass flavon