Moutan High Performance Liquid Chromatography pharmacophore fingerprint research.doc

 PAGE \* MERGEFORMAT 8 Moutan High Performance Liquid Chromatography ‘pharmacophore fingerprint’ research Author: Zhou Yan, Liang Wang, Shu-Mei Wang, Wu Mingxia, Chen Chunyan [Abstract] Objective To identify moutan blood circulation Huayu able to represent the role of high-performance liquid chromatography (HPLC) pharmacophore fingerprints. Methods moutan extracts of samples of different blood circulation Huayu experimental study in mice, at the same time HPLC analysis of extracts obtained in different parts of moutan fingerprints, and then the use of mathematical statistics software to analyze efficacy indices and fingerprint information about the relationship between the . The results determine the methanol extracts of the HPLC map to develop the efficacy moutan fingerprints. Conclusion The method developed fingerprints obtained more practical value, and more scientific and reasonable. [Keywords:] moutan blood circulation Huayu HPLC fingerprint efficacy Abstract: ObjectiveTo find out the Pharmacodynamic Fingerprint which can represent the action of activating blood circulation to dissipate blood stasis. MethodsTaking the samples of different parts for the study of activating blood circulation to dissipate blood stasis, at the same time, taking them for the study of HPLC to gain the fingerprints of different parts, and then the correlation between the pharmacological indexes and the information of the HPLC fingerprint was discovered by the statistic software. ResultsThe fingerprint of the methanol part could represent the Pharmacodynamic Fingerprint of Cortex Moutan.ConclusionThe fingerprint established by this method not only represents the chemistry information but also reflects its validity, it makes the study of fingerprint more scientific and reasonable. Keywords:: Cortex Moutan; Activating blood circulation to dissipate blood stasis; HPLC; Pharmacodynamic Fingerprint Moutan is a commonly used traditional Chinese medicine, to close contained in th