MUC6 gene a single nucleotide polymorphism is not associated with gastric cancer.doc

 PAGE \* MERGEFORMAT 6 MUC6 gene a single nucleotide polymorphism is not associated with gastric cancer Study: Yan Yan Gao Jing Jia Yanbin Zhang Jianzu [Abstract] Objective: To detect the mucin MUC6 gene single nucleotide polymorphisms (SNPrs7943115 and gastric cancer. Methods: TaqMan method 272 gastric cancer patients and 374 healthy individuals for genotyping, and use non-conditional Logistic regression SNP analysis and detection of gastric cancer. Results: MUC6 gene SNP is not associated with gastric cancer. Conclusion: SNP7943115 in the pathogenesis of gastric cancer not play a major role. [Keywords:] gastric mucin, MUC6 gene, single nucleotide polymorphism Abstract Objective: To evaluate the association of rs7943115 in the MUC6 gene of mucin with the risk of gastric cancer. Methods: SNP rs7943115 were genotyped among 272 cases with gastric cancer and 374 normal controls by TaqMan method. And data were analyzed using unconditional logistic regression to evaluate the association of the SNP with gastric cancer. Results: No association was found between the SNP examined in the present study and the incidence of gastric cancer. Conclusion: SNP rs7943115 does not play a major role in the development of gastric cancer. Keywords: Gastric cancer; Mucin; MUC6; Single nucleotide polymorphism (SNP) H. pylori has been identified as the World Health Organization stomach carcinogens. However, about half of the people in the world infected with H. pylori, only a very small number of people eventually develop into cancer, genetic factors explain individual occurrence of the disease process played an important role [1]. has now been confirmed, gastric cancer is a complex polygenic disease. In humans, Helicobacter pylori in gastric mucosal layer primarily sojourn, and mucosal mucus layer is mucin major components [2]. normal Gastric mucin specifically expressed MUC6 [3]. Studies have shown that the process of MUC6 in gastric cancer gene expression abnorma