Multi-channel multi-stage cervical cancer evolution tree model construction.doc

 PAGE \* MERGEFORMAT 6 Multi-channel multi-stage cervical cancer evolution tree model construction Author: Liu takeoff, Huang Zhong Xi, Zhi-Hua Yin, Kai-Tai Yao [Abstract] Objective-based comparative genomic hybridization of cervical cancer information cervical cancer to build a tree model to explore the evolution of cervical cancer development in multi-channel mode. Methods According to the complete collection of 58 cases of cervical cancer comparative genomic hybridization data, such as the use of established tumors Desper tree model software platform to build a tree model of cervical cancer. Cervical tree model results suggest that there are six non-random chromosomal amplification or deletion occurred in the course of cervical change: 1q, 3q, 5p, 17q, 20q, and 20p, which 3q and 1q may be important in cervical cancer an early event; 3q first place in 17q, and that may exist between the two has dependencies; and, 1q may be a relatively independent events; these amplified chromosome that may exist and cervical cancer occurrence and development are closely related to the evolution of oncogene. Conclusion is based on comparative genomic hybridization data to build a tree model of cervical cancer, suggesting that multi-stage cervical cancer, multi-channel evolution model of development, but also for the follow-up of cervical cancer-related genes indicate the direction of exploration. [Keywords:] cervical cancer; comparative genomic hybridization; tree model Abstract: Objective Based on CGH (comparative genomic hybridization, CGH) data, to construct tree model of cervical carcinoma and to explore multipathway model of cervical carcinoma progression. Methods Using the software which Desper et al developed, tree models of cervical carcinoma were constructed according to the CGH data of 58 cervical carcinoma patients. Results Tree models for cervical carcinoma suggested that there were 1q, 3q, 5p, 17q, 20q and 20p six nonrandom genetic events, and 1q and 3q might