Multi-index detection of tuberculosis and differential diagnosis of malignant pleural effusion.doc

 PAGE \* MERGEFORMAT 5 Multi-index detection of tuberculosis and differential diagnosis of malignant pleural effusion Author: Ye east, Ng Kwok-wai, SEATTLE [Abstract] Objective To lipoarabinomannan IgG antibody (LAM-IgG), M. tuberculosis DNA (TB-DNA), adenosine deaminase (ADA), carcinoembryonic antigen (CEA) and CEA-mRNA and so a number of indicators pairs of tuberculous and malignant pleural effusion for identification. Method of tuberculous pleural effusion (TB group) and malignant pleural effusion (malignant group) of the 53 cases, collecting specimens for the detection of pleural effusion, applications dot immunogold filtration assay to detect LAM-IgG, enzyme reaction end point assay ADA, MAIA technology Detection of CEA, polymerase chain reaction (PCP) to detect TB-DNA and CEA-mRNA. The results of LAM-IgG, TB-DNA, ADA, CEA and CEA-mRNA positive results were as follows: TB Group 32 (60.38%), 38 (71.70%), 44 (83.02%), 3 (5.66%) and 4 ( 7.55%), malignant group 4 (7.55%), 2 (3.77%), 8 (15.09%), 31 (58.49%) and 43 (81.13%), the difference between the two groups are highly significant (P all amp;quot;0.01) . Conclusion LAM-IgG, TB-DNA in the diagnosis of TB pleural effusion has a high specificity and sensitivity, CEA, CEA-mRNA in the diagnosis of malignant pleural effusion has a high specificity and sensitivity, ADA for the diagnosis of two kinds of hydrothorax specificity low, but high sensitivity, multi-index of common applications for differential diagnosis of tuberculous and malignant pleural effusion has a high application value. [Keywords:] pleural effusion; pleural effusion, malignant; tuberculosis; carcinoembryonic antigen; adenosine deaminase Pleural effusion is a common clinical, tumor, tuberculosis and other causes pleural effusion can be caused by the emergence of right pleural effusion is a clinical diagnosis and treatment determine the cause of pleural effusion sign the necessary basis for decision-making. We use lipoarabinomannan-IgG antibod