Multi-drug combination therapy clinical study of peptic ulcer with cirrhosis.doc

 PAGE \* MERGEFORMAT 11 Multi-drug combination therapy clinical study of peptic ulcer with cirrhosis [Abstract] Objective: To observe the propranolol, viable bifidobacterium preparations, famotidine triple regimen with colloidal bismuth subcitrate, amoxicillin, furazolidone triple in the treatment of Helicobacter pylori (Hp)-positive peptic ulcer patients with liver cirrhosis (PU) 2 weeks of treatment. Methods: 59 patients diagnosed with cirrhosis of the liver and confirmed by endoscopy combined diameter ofgt; = 3 mm of the active and confirmed by the rapid urease test positive Hp PU, random will be divided into A, B groups, Group A 30 cases given propranolol 30 ~ 120 mg / d, orally 3 times (in resting heart rate decreased by 20% to 25% for the degree), viable bifidobacteria preparation 100 ml, famotidine 20 mg, both orally 2 times a day; Group B 29 cases given colloidal bismuth subcitrate 120 mg, before meals and at bedtime daily oral amoxicillin 0.5 g, furazolidone 0.1 g were taken before bedtime and after meals daily. The treatment lasted 2 weeks. Results: Group A healing rate, the total efficiency and Hp eradication rates were 70.0%, 96.7% and 26.7%, respectively, 31.0 B %, 69.0% and 82.8% in group B, the difference was statistically significant (P lt;0.05). including gastric ulcer (GU) healing rates, and the total efficiency and the Hp eradication rate of Group A were 73.7%, 100.0% and 26.3%, Group B were 40.0%, 75.0% and 80.0%; duodenal ulcer (DU) healing rate and total effective rate of Hp eradication of Group A were 63.6%, 90.9% and 27.2%, respectively, B 22.2%, 55.6% and 88.9%, GU, DU A, B between the two groups, the differences were statistically significant (P lt;0.05). Conclusion: To reduce portal hypertension, cirrhosis of the liver against endotoxin help PU patients healed; Hp infection has nothing to do with the type of PU formation, for eradication of Hp-positive patients without treatment. [Keywords:] liver cirrhosis; Helicobacter p