Myocardial hypertrophy and changes in vasoactive substances butanol extract Polygonum relationship.doc

 PAGE \* MERGEFORMAT 11 Myocardial hypertrophy and changes in vasoactive substances butanol extract Polygonum relationship Of: Liliang Dong, Zhou Qin, Zhi-Hua Huang, Jing has been *, Zhang Xiangcheng, Wang Youbiao [Abstract] Objective To observe the butanol extract of Polygonum on isoproterenol (Iso induced cardiac hypertrophy and its effect on the protection of ANG , ANP and ET content. Methods Iso 1 mg kg-1 d-1, subcutaneous injection, continuous 10 d, rat model of cardiac hypertrophy. 2 day modeling treated with different concentrations of butanol extract Polygonum or NS, continuous 14 d, fasting for 12 after the last administration h, weighed and decapitated after anesthesia blood, take heart weighed and calculated parameters of left ventricular weight, measured by radioimmunoassay in plasma and cardiac tissue ANG ANP and ET levels. the result parameters of the model group significantly improved left ventricular mass, and plasma ANG myocardial ET content increased, decreased myocardial ANP, compared with model group, n-butanol extract of Polygonum left ventricular mass index decreased in treatment group, plasma and cardiac tissue ANG ET decreased, cardiac tissue ANP content increased. Conclusion Polygonum Iso butanol extract on cardiac hypertrophy induced protective effect, the mechanism of ANP with increased vasodilators and reduce the activity of vasoconstrictor substances in the level of ET and ANG relevant. [Keywords:] Polygonum butanol extract, isoprenaline, myocardial hypertrophy, vasoactive substances Polygonum with heat, Anticonvulsant, the rationale for the wet and other effects. Polygonum extract by 95% ethanol, then washed with petroleum ether, ethyl acetate, butanol, n-butanol part of its derived butyl Polygonum alcohol extract (Polygonum Bistorla L. n-Butyl Alcohol Extract, PBNA, the main component of clove and rutin, catechin and Mururin A [1]. There experiments show that, PBNA with anti-arrhythmia [2], analgesic [3], central